Best Over The Counter Sleep Aids

When choosing an over the counter sleeping pill, the first decision to make is whether to take one containing melatonin, an anti-histamine or a herbal remedy.

A basic rule of thumb to understand the difference is as follows:

  • Anti-histamines – generally have the strongest sedative effect.
  • Melatonin – helps regulate sleep after disruption due to events like jet-lag or shift work.
  • Herbal pills – usually have the lightest effect.

In this review you’ll find out about the best over the counter sleep aids in the Melatonin and anti-histamine category, and a popular one which combines melatonin with herbal ingredients.

Some of these sleeping pills are strong even though they are non-prescription, so please ensure you read the reviews carefully.


1) Kirkland Signature

Strongest overall sedative effect

Price: $11.99 for 192 pills

kirkland sleep aid

In the anti-histamine category Kirland Signature is one of the strongest and most effective over the counter sleep aids you’ll find. Furthermore, it’s by far the strongest overall in all 3 of the categories in this review.

The active ingredient is Doxylamine, which is one of the most powerful anti-histamine sedatives. You’re likely to feel very drowsy (physically and mentally) after taking a Kirkland sleeping tablet, which is of course what you would hope for.

It’s great if you plan on having a long night’s sleep, as it should help you past the annoying period of insomnia you may be experiencing.

It may not be ideal, however, if you’re planning on going to bed late and getting up early in the morning.

There’s no official statement on the exact number of hours that it stays in the body, as it will depend on various factors such as your size, metabolism and age.

So to be on the safe side, it’s probably best to keep in mind that if you plan on getting up less than 8 hours after taking it and rushing out of the house to work, you may still feel a bit drowsy.

But if you have time on your hands to get a good night’s sleep and wake up slowly, then the Kirkland sleep aid could suit you well. And of course, you can manage the time it stays in your system by taking it a while before you go to sleep, and ensuring you have plenty of time dedicated to sleeping.

In terms of safety, people don’t usually develop a tolerance to Doxylamine as quickly as some other anti-histamines. And it’s not known to cause problems with addiction like many prescription sleeping pills do.

So if you’re planning on using an over the counter sleeping pill for between a night and a few weeks, Kirkland is an excellent choice.

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2) Unisom SleepGels

Milder sedation if you need just a little something to help you sleep

$10.98 for a pack of 60

unisom sleep gels

Unisom Sleepgels contain the other type of antihistamine typically found in sleeping pills – Diphenhydramine hydrochloride.

There are 3 main versions available – SleepGels, SleepTabs and QuickMelts. The difference being in whether each tablet contains 25mg or 50mg, and how quickly it’s absorbed by the body.

Unisom doesn’t pack the same punch as Kirkland in terms of its strength of knock-out. But it’s useful if you just need a little extra to help you sleep and don’t want to feel the effects into the next day.

Although, as with many sedatives you may feel a little groggy first thing in the morning depending on how sensitively you react to them.

It’s possible to build a tolerance to this type of anti-histamine compared to the Kirkland sleep aid. So if you find yourself feeling the need to increase the dosage above the recommended level, then it’s a sign you should speak to your doctor or stop taking them.

Overall, Unisom is perhaps the best over the counter sleep aid if you want to try an anti-histamine for the first time, but would prefer a lighter introduction to this kind of sleeping pill.

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3) Mel-O-Chew

Most effective melatonin sleep aid

Price: £10.99 for 100 tablets

bottle of 100 mel-o-chew melatonin sleeping pills

Mel-O-Chew is a popular chewable Melatonin-based sleep aid. Melatonin being the hormone produced in your body which does the job of telling your internal body clock when it’s time to go to sleep, and when it’s time to wake up.

The idea then is that this synthetic version can boost the amount you naturally have in the body, and therefore help regulate your body clock.

Mel-O-Chew is not as powerful as most prescription sleeping pills, or even the anti-histamine sleep aids in general.

But it works in a completely different way: rather than simply knocking you out it helps you to keep to a normal sleeping time. And that way it’s promoted as being more natural than pharmaceutical pills or anti-histamines.

The thing to remember is that Melatonin is only thought to be useful in certain circumstances. There is scientific evidence that it helps with jet-lag, shift work, delayed sleep phase syndrome and possibly insomnia for older people.

But there isn’t much evidence that it will help anyone with insomnia. Having said that though, some people still swear by it, so you probably won’t really know if it’ll work for you until you try it.

If you’re in the category of people who melatonin can help though, then Mel-O-Chew is one of the best otc sleep aids available.

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4) Source Naturals

Fast-acting melatonin

Price: £14.10 for 240 tablets

source naturals melatonin

Source Naturals is another Melatonin based sleeping tablet, made by a company with a reputation for producing high quality supplements.

The Source Naturals pills are sub-lingual which means they dissolve under the tongue. They are therefore absorbed into the bloodstream faster than normal pills, and so take action very quickly.

As with all melatonin sleeping tablets, they will only work for certain sleep conditions (see the Mel-O-Chew explanation above). But if you do fall into one of those categories, Source Naturals should help you get some rest at night.

So if you’re looking for a fast-acting melatonin based product, Source Naturals is a reliable and effective option.

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5) Vitafusion SleepWell

Combination of melatonin and natural herbs

Price: $19.45 for 120 tablets

Vitafusion Sleep Well Gummy tablets

Vitafusion is another well-respected brand of supplements, and they have created an interesting concoction of natural ingredients in the SleepWell tablets.

Again containing Melatonin, this would usually mean they would only work for the same sleep problems as the two other melatonin pills in the review.

However, the inclusion of Passion Flower, Chamomile and Lemon Balm means it’s not so easy to ignore the possibility of it helping other sleep problems such as insomnia.

Here at No Sleepless Nights I often talk about how there isn’t much evidence that herbal remedies actually work. But despite the lack of hard evidence, people still say they do help.

So it probably boils down to a willingness to try them out yourself and see what happens. With the combination of melatonin and herbs it’s impossible to guess whether they will actually help you or not.

But they are proving very popular, scoring nearly 5 stars on amazon for example, which is very rare for a sleeping pill.

And the fact that they are a chewable gummy means they are one of the best over the counter sleeping pills when it comes to how easy they are to swallow, and the fact that they only contain natural ingredients.

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